Bioinformatics, NGS Application Development Intern

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At Exact Sciences, we're helpingchange how the world prevents, detects and guides treatment for cancer. We give patients and clinicians the clarity needed to make confident decisions when they matter most. Join our team to find a purpose-driven career, an inclusive culture, and robust benefits to support your life while you're working to help others.

Position Overview

Project: In-silico test data sets for development, evaluation, testing, validation and monitoring of NGS pipelines and tools.

Develop tools to create in-silico data sets with known mutations that can be used for tool development: evaluation, testing, validation, and monitoring of NGS products. This project will entail designing and developing tool(s) to mutagenizing sequencing data from DNA control data to create in-silico data with known mutations. The tool should allow for creating data sets with SNV, MNV, copy number, and/or structural variants. In addition, a tool that downsamples to generate samples that can facilitate expedited testing of pipeline workflows. A stretch goal for the project will be the development of tools for mutagenizing RNA data.

Summer 2025

Essential Duties

Include, but are not limited to, the following:

• Apply software engineering skills to create reusable, modular, tested, version-controlled, shared repository oriented, and professional quality informatics, software, and database resources.
• Incorporate knowledge of genomics when applying variant types to new use cases
• Utilize basic statistics to understand the impact of a change to bioinformatic algorithms.
• Display strong debugging skills when working with unfamiliar software.
• Excellent communication and organizational skills.
• Incorporate efficient and high-quality practices when working with technology.
• Suggest and explore alternative or multiple data processing approaches.
• Exercise ability to write software dynamically as a team and independently.
• Uphold company mission and values through accountability, innovation, integrity, quality, and teamwork.
• Strong drive to interact with researchers carrying out cutting-edge biomedical research.
• Support and comply with the company's Quality Management System policies and procedures.
• Ability to act with an inclusion mindset and model these behaviors for the organization.

Scheduling requirements:

• Ability to work designated schedule.

Physical requirements:

• Ability to work on a mobile device, tablet, or in front of a computer screen and/or perform typing for approximately 85% of a typical working day.
• Ability to work on a computer and phone simultaneously.
• Ability to use a telephone through a headset.

Minimum Qualifications

• Currently enrolled in a Master's degree in Bioinformatics/Computer Science/Bioengineering/Computational Biology or related field.
• Experience with next-gen sequencing and genomic technologies (e.g. IGV).
• Demonstrated proficiency in Python.
• Demonstrated proficiency with cloud computing (e.g. AWS).
• Demonstrated ability to successfully download, learn, and apply software and database resources for custom analysis and build workflows.
• Demonstrated understanding of scientific computing and programmatic data visualization tools, and of basic statistics.
• Demonstrated proficiency using Linux/UNIX based systems and shell scripting.
• Demonstrated familiarity with large-scale data analysis and utilization of high-performance computing systems and parallel programming.
• Ability to programmatically interact with data.
• Preference giving to candidates with a record of outstanding academic achievement.
• Basic proficiency with Microsoft Word and Excel.
• Demonstrated ability to perform the essential duties of the position with or without accommodation.
• Authorization to work in the United States without sponsorship.

Salary Range:

Exact Sciences is proud to offer an employee experience that includes paid time off (including days for vacation, holidays, volunteering, and personal time), paid leave for parents and caregivers, a retirement savings plan, wellness support, and health benefits including medical, prescription drug, dental, and vision coverage. Learn more about our benefits.

Our success relies on the experiences and perspectives of a diverse team, and Exact Sciences fosters a culture where all employees can develop personally and professionally with a sense of respect and belonging. If you require an accommodation, please contact us here.

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We are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to age, color, creed, disability, gender identity, national origin, protected veteran status, race, religion, sex, sexual orientation, and any other status protected by applicable local, state, or federal law. Any applicant or employee may request to view applicable portions of the company's affirmative action program.

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