Associate Scientist

Position Title: Scientist - II (Associate)

Work Location: Cambridge, MA 02141

Assignment Duration: 12 months

Work Arrangement: 100% onsite

Notes:

• At least 2 years of experience focusing on single cell.
• We are 100% looking for wet lab expertise on single cell library generation.
• Cell handling for single cell.
• Library gene.
• NGS library prep.
• 10X Genomics is required, Parse, Scale Bio is nice to have.
• Bioinformatics is nice to have.
• Single cell transcriptomic, no spatial experience is required.

Position Summary: Seeking a skilled scientist with expertise in single cell omics data generation and cell handling to support initiatives in the Data, AI, and Genome Sciences department.

Background & Context:

• This contract position requires exceptional interpersonal and problem-solving abilities, along with a proven track record of collaboration in cross-functional teams.
• You will be instrumental in supporting innovative single cell omics workflows and applying advanced single cell assays to enhance discovery and validation processes.
  
  Key Responsibilities:
• Prepare high-quality cell and nuclei samples for single cell assays.
• Design and execute large-scale workflows for single cell assays, focusing on cell preparation and library generation across various platforms using automation (e.g., 10X Genomics 3'/5' and Flex assays, Parse, Scale Bio, etc.).
• Perform library quantification and sequencing of single cell libraries utilizing Illumina platforms (e.g., NovaSeq).
• Collaborate closely with experimental biologists to address biological inquiries, develop workflow strategies, and formulate experimental plans.
• Clearly communicate and document assay procedures and workflows for both computational and experimental teams through comprehensive reports and presentations, facilitating efficient analysis and planning.
• Keep abreast of the latest developments in single cell technologies, computational techniques, and relevant biological disciplines.
• Ensure meticulous documentation of workflows and experimental results.
  
  Qualification & Experience:
• A Master's or Ph.D. in Biological Sciences or a closely related field, complemented by relevant practical experience as outlined below.
• A minimum of two (2) years of hands-on research experience focused on cell preparation for single cell transcriptomics and multi-omics, including library creation and quality assessment for diverse sample types.
• Proficiency in using automation tools for library creation and sample processing.
• A thorough understanding of the data requirements necessary for single cell transcriptomics.
• A solid background in single cell data analysis is advantageous.
• Direct experience with various single cell profiling technologies (e.g., 10X Genomics 3'/5' and Flex assays, Parse, Scale Bio, etc.).
• Experience in cell culture and cell handling.
• Strong problem-solving abilities, critical thinking skills, and analytical expertise.
• Excellent communication skills, both written and verbal, with the ability to convey complex technical information to a wide range of audiences.
• Ability to work effectively both independently and as part of a multidisciplinary team.
• Experience in analyzing single cell transcriptomic data (preferred).
• Familiarity with specific biological areas related to immune-mediated or metabolic diseases (preferred).
• Experience in designing workflows for single cell assays (preferred).
• A strong publication history in reputable peer-reviewed journals (preferred).