Scientist 3, Cell Therapy, in vivo delivery

We advance science so that we all have more time with the people we love.

The newly formed Cell Therapy department in gRED (Genentech Research and Early Development) is looking for a motivated and inquisitive Scientist to help develop novel therapies to combat intractable diseases. We are looking for a candidate with a scientific background in delivery particles for cell therapy applications, coupled with a resourceful aptitude for problem-solving. The successful applicant will display a proactive and collaborative work ethic, proficiently engaging and communicating across diverse teams with the shared goal of contributing to the Genentech cell therapy pipeline. This position will report to a Principal Scientist and play a pivotal role in shaping the growth, culture and future of the Cell Therapy Research department.

The Opportunity:

• Plan, conduct, and analyze experiments leveraging a diversity of delivery modalities (viral and/or non viral) to support in vivo and ex vivo cell therapy efforts at Genentech

• Design and engineer novel delivery vehicles for the in vivo engineering of immune cells

• Develop and implement assays to characterize and validate in vivo generated cells

• Actively collaborate with groups both within and outside gRED, on scale up and manufacturing

• Maintain comprehensive and accurate experimental records utilizing electronic tools

• Participate and contribute to strategic planning enabling the contribution of the Cell Therapy department to Genentech's pipeline

Who you are:

• PhD with 3+ years of relevant experience, a Master's with 6+ years of experience, or a Bachelor's with 8+ years of experience

• You will have direct experience with in vivo cell therapy or gene therapy, including construct design and functional characterization

• You will have a record of scientific contributions evidenced by co-authorship of papers, patents, or IND reports, and/or significant contribution to a gene or cell therapy pipeline

• You will have a robust background in viral-like particle or lentivirus engineering, characterization, and scale-up

• Experience with culturing primary T cells and/or iPSCs, and conducting lentiviral screens or gene editing on them

• Proficiency with functional readout assays such as flow cytometry, ddPCR/qPCR, NGS, and RNA-seq

• An inherent team player with strong communication skills, able to prioritize team objectives and collaborate effectively

• Strong work ethic, scientific curiosity, rigor, and a keen eye for detail

Preferred

• Familiarity with the development of cell therapy products (e.g. pipeline progression, process development, good manufacturing practices) is desired

• Additional skillset of interest could include: CRISPR screens or high-throughput transgene expression screens, protein engineering. Experience with data analysis and/or programming is a big plus

Relocation benefits are available for this posting.

The expected salary range for this position based on the primary location of California is $101,400 to $188,200. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.