Staff Scientist

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world's leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world's deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems.

The Li Research Group (https://research.fredhutch.org/haolong-li/en.html) at Fred Hutch Cancer Center has an opening for a Staff Scientist interested in prostate cancer research and biomarker development.

The Staff Scientist will provide technical and scientific guidance to a highly motivated group of early-stage postdoctoral fellows and research technicians. Our lab focuses on epigenetic dysregulation and novel therapeutics in advanced prostate cancer, using a systems biology approach.

Projects combine CRISPR-based functional screens (knockout, interference, activation) with transcriptomics, proteomics, and epigenomics to uncover therapeutic vulnerabilities. Areas of interest include androgen receptor signaling, mechanisms of therapeutic resistance, aberrant DNA methylation, and the role of mutations in TET2, IDH1, and other chromatin-modifying genes.

The Staff Scientist will work side-by-side with a team of post-doctoral fellows and technicians to plan, design and implement experiments on a variety of projects in basic and translational cancer research and perform other tasks as required.

MINIMUM QUALIFICATIONS:

Ph.D. in the field of Cancer Biology or Molecular Biology and experience in a related area and with at least 8 years post-PhD work experience.
• Knowledge of cancer biology and experience working with both in vitro and in vivo cancer models.
• Technical laboratory skills in molecular biology and biochemistry. Specific expertise in Western blotting, Real-time quantitative PCR, cloning, mammalian cell culture, lentiviral transduction, immunoprecipitation and chromatin immunoprecipitation (ChIP), flow cytometry, and animal models is strongly preferred.
• Must have previous first author publication(s).
• The candidate should be enthusiastic about this research area, goal-oriented, a self-starter, and be able to work in a team environment.
• Strong analytical, writing, communication and problem-solving skills are required.

The annual base salary range for this position is from $82,118 to $185,016, and pay offered will be based on experience and qualifications.

Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, tuition reimbursement, paid vacation (22 days per year), paid sick leave (up to 30 calendar days per occurrence of a qualifying reason), paid holidays (up to 13 days per year), paid parental leave (up to 4 weeks), and partially paid sabbatical leave (up to 12 months for professor track faculty, up to 6 months for other scientific staff).