Laboratory Science Professional (Open Rank: Entry - Principal)

Job Summary:

Our group takes an integrative approach that combines biophysical, biochemical, and biological methods to fully characterize macromolecular interactions that underlie disease progression. We utilize state-of-the-art techniques such as nuclear magnetic resonance (NMR) and cryo-electron microscopy (cryo-EM) to investigate atomic-resolution details of enzymes involved in infectious disease, cancer, and inflammation. Ongoing projects include:

1. Bacterial proteases: Determining mechanisms of activation, protease specificity, and developing antimicrobial inhibitors.
2. Bacterial metabolism: Characterizing novel metabolic enzymes.
3. Cancer and inflammation: Investigating redox regulation and cellular signaling proteins.
4. Enzyme dynamics: Studying allosteric mechanisms in key enzymes.

We are seeking a laboratory professional at any level who is motivated to apply and expand a wide array of experimental techniques. Training in specialized methods such as NMR and cryo-EM will be provided as needed.

Examples of Duties Performed

• Molecular engineering (PCR)
• Recombinant protein expression and purification (FPLC, HPLC)
• Gel electrophoresis (protein and DNA)
• Nuclear Magnetic Resonances (data collection, spectral assignments, relaxation experiments)
• EM/Cryo-EM (data collection, refinement)

Additional Duties & Responsibilities:

• Collaborate with and support other investigators with laboratory and research functions
• Utilize a variety of laboratory techniques required for research projects
• Perform experiments and tabulate and analyze research
• Perform pre-analytical, analytical and post analytical test process and evaluate results produced
• Prepare lab for daily operations, including stocking materials, equipment, safety, cleanliness, and related areas
• Dispose of laboratory materials and samples using well established guidelines and instructions
• Review, complete and process logs, documents, databases, and related materials and information
• Assist in the review and implementation of lab support policies, practices and programs to meet organizational, operations and management needs

Laboratory professionals in this position will work in an experimental (wet) lab environment, handling biological samples and analyzing data using NMR and EM methods, which require a strong level of computer skills.

For more details, please visit: https://medschool.cuanschutz.edu/biochemistry/people/primary-faculty/eisenmesser-elan

Work Location:

Onsite - this role is expected to work onsite and is located in Aurora, CO.

Why Join Us:

Our department conducts research across a wide biological scale for fundamental scientific understanding with applications to many disease contexts. The overarching goal is to reach a level of molecular insight that helps develop therapeutic approaches to disease.

As biochemists and molecular geneticists, we are amid an unprecedented time of discovery - our conception of the molecular biology of cells is going from the equivalent of grainy black-and-white to high-resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes, and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell's machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefronts of their fields both conceptually and technologically.

The University of Colorado offers a comprehensive benefits package that includes health insurance, life insurance, retirement plans, tuition benefits, ECO pass, paid time off - vacation, sick, holidays and more. To see what benefits are available, please visit: https://www.cu.edu/employee-services/benefits-wellness.

Qualifications:

Minimum Qualifications:

Entry Professional:

• Bachelor's degree in chemistry, biology, molecular biology or a related field
  
  
  
  • A combination of education and related technical/paraprofessional experience may be substituted for the bachelor's degree on a year for year basis
  
  
  
  

Intermediate Professional:

• Bachelor's degree in chemistry, biology, molecular biology or a related field
  
  
  
  • A combination of education and related technical/paraprofessional experience may be substituted for the bachelor's degree on a year for year basis
  
  
  
  
• One (1) year professional level research experience

Senior Professional:

• Bachelor's degree in biology, molecular biology, chemistry, genetics or related field
  
  
  
  • A combination of education and related technical/paraprofessional experience may be substituted for the bachelor's degree on a year for year basis
  
  
  
  
• Two (2) years professional level research experience

Principal Professional

• Bachelor's degree in biology, molecular biology, chemistry, genetics or related field
  
  
  
  • A combination of education and related technical/paraprofessional experience may be substituted for the bachelor's degree on a year for year basis
  
  
  
  
• Three (3) years professional level research experience

Required: Applicants must meet minimum qualifications at the time of hire.

Preferred Qualifications:

• One (1) to Two (2) years of experience or background within an experimental or wet lab
• Prior experience in analytical chemistry, especially ultra-high pressure liquid chromatography coupled to mass spectrometry

Entry Professional:

• Knowledge of basic laboratory techniques including safety procedures and techniques
• Ability to communicate effectively, both in writing and orally
• Ability to establish and maintain effective working relationships with employees at all levels throughout the institution
• Ability to interpret and master complex research protocol information

Intermediate Professional:

• Proficient knowledge of basic laboratory techniques including safety procedures and techniques
• Ability to communicate effectively, both in writing and orally
• Ability to establish and maintain effective working relationships with employees at all levels throughout the institution
• Ability to interpret and master complex research protocol information

Senior Professional:

• Advanced knowledge of laboratory techniques including safety procedures and techniques
• Ability to communicate effectively, both in writing and orally
• Ability to establish and maintain effective working relationships with employees at all levels throughout the institution
• Ability to interpret and master complex research protocol information

Principal Professional:

• Expert knowledge of laboratory techniques including safety procedures and techniques
• Expert ability to analyze and solve complex problems
• Ability to communicate effectively, both in writing and orally
• Ability to establish and maintain effective working relationships with employees at all levels throughout the institution
• Ability to interpret and master complex research protocol information
• Higher-level knowledge of Structural Biology, Instrumentation, and Computational Biology processes, functions and/or technology

How to Apply:

For full consideration, please submit the following document(s):

1. A letter of interest describing relevant job experiences as they relate to listed job qualifications and interest in the position.

2. Curriculum vitae / Resume

3. Three to five professional references, including name, address, phone number (mobile number if appropriate), and email address.

Questions should be directed to: Elan Eisenmesser, elan.eisenmesser@cuanschutz.edu

Screening of Applications Begins:

Immediately and continues until position is filled. For best consideration, apply by May 2, 2025

Anticipated Pay Range:

The starting salary range (or hiring range) for this position has been established as

Entry Professional: $46,274- $58,861

Intermediate Professional: $50,357 - $64,054

Senior Professional: $54,440- $69,248

Principal Professional: $62,606 - $79,635

The above salary range (or hiring range) represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting. This position may be eligible for overtime compensation, depending on the level.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.

Total Compensation Calculator: http://www.cu.edu/node/153125

Equal Employment Opportunity Statement:

The University of Colorado (CU) is an Equal Opportunity Employer and complies with all applicable federal, state, and local laws governing non-discrimination in employment. We are committed to creating a workplace where all individuals are treated with respect and dignity, and we encourage individuals from all backgrounds to apply.

ADA Statement:

The University will provide reasonable accommodation to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act, please contact the Human Resources ADA Coordinator at hr.adacoordinator@cuanschutz.edu.

Background Check Statement:

The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students, and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.

Vaccination Statement:

CU Anschutz strongly encourages vaccination against the COVID-19 virus and other vaccine preventable diseases. If you work, visit, or volunteer in healthcare facilities or clinics operated by our affiliated hospital or clinical partners or by CU Anschutz, you will be required to comply with the vaccination and medical surveillance policies of the facilities or clinics where you work, visit, or volunteer, respectively. In addition, if you work in certain research areas or perform certain safety sensitive job duties, you must enroll in the occupational health medical surveillance program.